Network analytical tools are increasingly being applied to brain imaging maps of resting
metabolic activity (PET) or blood oxygenation-dependent signals (functional MRI) to …

Synaptic dysfunction and altered synaptic pruning are present in people with Parkinsonian
disorders. Dopamine loss and alpha‐synuclein accumulation, two hallmarks of Parkinson's …

Highlights Imaging of the dopamine transporter (DAT)(in particular using 11C-or 18F-PE2I)
most reliably and precisely measures neurodegeneration of the dopaminergic system in …

ABSTRACT Background Idiopathic Parkinson's disease (iPD) is associated with two distinct
brain networks, PD‐related pattern (PDRP) and PD‐related cognitive pattern (PDCP), which …

Network analysis of functional brain scans acquired with [18 F]-fluorodeoxyglucose positron
emission tomography (FDG PET, to map cerebral glucose metabolism), or resting-state …

Purpose Whether the intrinsic functional connectivity pattern of the default mode network
(DMN) is involved in the progression of cognitive decline in Parkinson's disease (PD) …

Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies.
Using positron emission tomography, we assessed changes in Parkinson's disease-related …

Notable success has been achieved in the study of neurodegenerative conditions using
reduction techniques such as principal component analysis (PCA) and sparse inverse …

Functional imaging has been used extensively to identify and validate disease-specific
networks as biomarkers in neurodegenerative disorders. It is not known, however, whether …

Primary dystonia is thought to emerge through abnormal functional relationships between
basal ganglia and cerebellar motor circuits. These interactions may differ across disease …