The immune system evolved to distinguish non-self from self to protect the organism. As
cancer is derived from our own cells, immune responses to dysregulated cell growth present …

Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At
present, GBMs are divided in primary and secondary on the basis of the mutational status of …

Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …

An extensive body of literature describes anticancer property of dichloroacetate (DCA), but
its effective clinical administration in cancer therapy is still limited to clinical trials. The …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

The basement membrane is an important extracellular matrix that is found in all epithelial
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

Melanomas are highly heterogeneous tumors, but the biological significance of their
different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU …

Glioblastoma multiforme (GBM) are mortifying brain tumours that contain a subpopulation of
tumour cells with stem-like properties, termed glioblastoma stem-like cells (GSCs). GSCs …