The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …

Cilia are hair-like membrane protrusions that emanate from the surface of most vertebrate
cells and are classified into motile and primary cilia. Motile cilia move fluid flow or propel …

Cilia are hair‐like structures that project from the surface of cells. In vertebrates, most cells
have an immotile primary cilium that mediates cell signaling, and some specialized cells …

Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

The pioneer works of Marc Dax and Paul Broca on the association between left hemisphere
injuries and speech impairments, revealed one of the most intriguing properties of the brain …

Motile cilia are hairlike organelles that project outward from a tissue-restricted subset of cells
to direct fluid flow. During human development motile cilia guide determination of the left …

Primary ciliary dyskinesia (PCD) is a hereditary genetic disorder caused by the lack of motile
cilia or the assembxly of dysfunctional ones. This rare human disease affects 1 out of 10,000 …

Rab and Arl guanine nucleotide‐binding (G) proteins regulate trafficking pathways essential
for the formation, function and composition of primary cilia, which are sensory devices …