Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
The MYCN proto-oncogene is amplified in a number of advanced-stage human tumors, such
as neuroblastomas. Similar to other members of the MYC family of oncoproteins, MYCN …
as neuroblastomas. Similar to other members of the MYC family of oncoproteins, MYCN …
[HTML][HTML] Regulation of proteolysis by human deubiquitinating enzymes
ZM Eletr, KD Wilkinson - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
The post-translational attachment of one or several ubiquitin molecules to a protein
generates a variety of targeting signals that are used in many different ways in the cell …
generates a variety of targeting signals that are used in many different ways in the cell …
USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway
H Sun, B Ou, S Zhao, X Liu, L Song, X Liu, R Wang… - …, 2019 - thelancet.com
Background USP11 is an ubiquitin-specific protease that plays an important role in tumor
progression via different mechanisms. However, the expression and prognostic significance …
progression via different mechanisms. However, the expression and prognostic significance …
Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1
K Taniue, A Kurimoto, H Sugimasa… - Proceedings of the …, 2016 - National Acad Sciences
Many long noncoding RNAs (lncRNAs) are reported to be dysregulated in human cancers
and play critical roles in tumor development and progression. Furthermore, it has been …
and play critical roles in tumor development and progression. Furthermore, it has been …
USP7 is a SUMO deubiquitinase essential for DNA replication
E Lecona, S Rodriguez-Acebes, J Specks… - Nature structural & …, 2016 - nature.com
Post-translational modification of proteins by ubiquitin (Ub) and Ub-like modifiers regulates
DNA replication. We have previously shown that chromatin around replisomes is rich in …
DNA replication. We have previously shown that chromatin around replisomes is rich in …
Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA
methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at …
methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at …
[HTML][HTML] The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer
Cancer is one of the deadliest diseases in the world causing record number of mortalities in
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …
both developed and undeveloped countries. Despite a lot of advances and breakthroughs in …