In recent years, G-quadruplexes (G4s), types of noncanonical four-stranded nucleic acid
structures, have been identified in many viruses that threaten human health, such as HIV …

RNA helicases constitute a large family of proteins that play critical roles in mediating RNA
function. They have been implicated in all facets of gene expression pathways involving …

In recent decades, vaccines have been extraordinary resources to prevent pathogen
diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or …

Zika virus (ZIKV) infection may lead to severe neurological consequences, including
seizures, and early infancy death. However, the involved mechanisms are still largely …

In recent years, globalization, global warming, and population aging have contributed to the
spread of emerging viruses, such as coronaviruses (COVs), West Nile (WNV), Dengue …

Drug candidates with poor solubility have been recognized as the cause of many drug
development failures, owing to the fact that low solubility is unfavorable for physicochemical …

Abstract The human DEAD-Box Helicase 3 X-Linked (DDX3X) is an ATP-dependent RNA
helicase involved in virtually every step of RNA metabolism, ranging from transcription …

Simple Summary In the last ten years, the human helicase protein DDX3X turned out to be
an extremely interesting target for the development of potential anticancer drugs. Herein, we …

Removal of ribonucleotides (rNMPs) incorporated into the genome by the ribonucleotide
excision repair (RER) is essential to avoid genetic instability. In eukaryotes, the RNaseH2 is …

The human genome is mainly transcribed into non-coding RNAs that are not translated into
proteins. With increasing understanding of function through continued research it has …