Beyond the joints, the extra-articular manifestations in rheumatoid arthritis

A Conforti, I Di Cola, V Pavlych, P Ruscitti… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is an inflammatory disease typically affecting the joints, but the
systemic inflammatory process may involve other tissues and organs. Many extra-articular …

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management

S Kadura, G Raghu - European Respiratory Review, 2021 - Eur Respiratory Soc
Rheumatoid arthritis (RA) is a systemic inflammatory disorder, with the most common extra-
articular manifestation of RA being lung involvement. While essentially any of the lung …

Next-generation regulatory T cell therapy

LMR Ferreira, YD Muller, JA Bluestone… - Nature reviews Drug …, 2019 - nature.com
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Autoimmune pre-disease

K Bieber, JE Hundt, X Yu, M Ehlers, F Petersen… - Autoimmunity …, 2023 - Elsevier
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Neutrophil extracellular traps (NETs) in autoimmune diseases: a comprehensive review

KH Lee, A Kronbichler, DDY Park, YM Park, H Moon… - Autoimmunity …, 2017 - Elsevier
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the
membranes of activated neutrophils. NETs are found in a variety of conditions such as …

Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

Emerging role of air pollution in autoimmune diseases

CN Zhao, Z Xu, GC Wu, YM Mao, LN Liu, YL Dan… - Autoimmunity …, 2019 - Elsevier
Autoimmune diseases (ADs) are a broad spectrum of disorders featured by the body's
immune responses being directed against its own tissues, resulting in prolonged …

No genetic causal association between periodontitis and arthritis: A bidirectional two-sample mendelian randomization analysis

KJ Yin, JX Huang, P Wang, XK Yang, SS Tao… - Frontiers in …, 2022 - frontiersin.org
Objectives Periodontitis (PD) has been linked to arthritis in previous epidemiological
observational studies; however, the results are inconclusive. It remains unclear whether the …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Osteoimmunology: a current update of the interplay between bone and the immune system

C Guder, S Gravius, C Burger, DC Wirtz… - Frontiers in …, 2020 - frontiersin.org
Immunology, already a discipline in its own right, has become a major part of many different
medical fields. However, its relationship to orthopedics and trauma surgery has …