Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …

The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the
exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic …

Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD)
such as Crohn's disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes …

Tumor necrosis happens commonly in advanced solid tumors. We reported that necroptosis
plays a major role in tumor necrosis. Although several key necroptosis regulators including …

Necroptosis mediated by Z-nucleic-acid-binding protein (ZBP) 1 (also called DAI or DLM1)
contributes to innate host defense against viruses by triggering cell death to eliminate …