Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Antiangiogenic and cytotoxic effects are considered the principal mechanisms of action of
sorafenib, a multitarget kinase inhibitor approved for the treatment of hepatocellular …

Cell‐fate determination is influenced by interactions between master transcription factors
(TFs) and cis‐regulatory elements. Hepatocyte nuclear factor 4 alpha (HNF4A), a liver …

Background Pancreatic adenocarcinoma (PAAD) is among the most lethal diseases and has
a dismal prognosis; however, efficient treatment is currently limited. Several studies have …

The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

DNA methylation deregulation at partially methylated domains (PMDs) represents an
epigenetic signature of aging and cancer, yet the underlying molecular basis and resulting …

Medulloblastoma (MB), the most common form of pediatric brain malignancy, has a low
frequency of oncogenic mutations but pronouncedly abnormal DNA methylation changes …

Tet-mediated DNA demethylation plays an important role in shaping the epigenetic
landscape and chromatin accessibility to control gene expression. While several studies …

DNA methylation of enhancers is dynamic, cell-type specific, and vital for cell fate
progression. However, current models inadequately define its role within the hierarchy of …