Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is
associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight …

Abstract Purpose of Review There is interest in evaluating the developmental origins of
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …

Abstract In1998, the Boston Birth Cohort (BBC) was initiated at Boston Medical Center
(BMC) in response to persistently high rates of preterm birth (PTB, defined as birth before 37 …

Epigenetic modifications control gene expression and are essential for turning genes on and
off to regulate and maintain differentiated cell types. Epigenetics are also modified by a …

Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential
impact on offspring neurodevelopment, and its association with childhood and adolescent …

Individual differences in drug response have always existed in clinical treatment. Many non‐
genetic factors show non‐negligible impacts on personalized medicine. Emerging studies …

Background DNA methylation (DNAm) in cord blood has been associated with various
prenatal factors and birth outcomes. This study sought to fill an important knowledge gap …

Prenatal tobacco exposure (PTE) and prenatal alcohol exposure (PAE) have been
associated with an increased risk of delayed neurodevelopment in children as well as …

Background Poor social support during pregnancy has been linked to inflammation and
adverse pregnancy and childhood health outcomes. Placental epigenetic alterations may …

Abstract Purpose of Review This review aims to analyse the currently reported gene-
environment (G× E) interactions in genome-wide association studies (GWAS), involving …