Angioedema without concomitant urticaria is a well-known complication of treatment with the
recombinant tissue-type plasminogen activator (r-tPA) alteplase and its genetically modified …

Background: A diagnosis of hereditary angioedema (HAE) with normal C1 esterase inhibitor
(HAE-nl-C1-INH) can be challenging and pharmacologic management is not well defined …

Hereditary angioedema (HAE) is a rare, potentially life‐threatening genetic disorder
characterized by recurrent attacks of swelling. Local vasodilation and vascular leakage are …

In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to
the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight …

Hereditary angioedema (HAE) is associated with episodic kinin-induced swelling of the skin
and mucosal membranes. Most patients with HAE have low plasma C1-inhibitor activity …

Angioedema is a clinical finding of intermittent, localized, and self-limiting swelling of
subcutaneous or submucosal tissue. While all forms of angioedema result from transiently …

Angioedema is the physical manifestation of transiently increased vascular permeability.
While originating from distinct underlying pathophysiologic mechanisms, collectively the …

Recurrent angioedema can present with or without wheals. Angioedema without wheals
may be driven by bradykinin and/or mast cell mediators. The different forms respond to …

Background and Objectives: Angioedema is a non-pitting edema of the submucosal layer
which can be acquired or inherited and usually presents with hives. Intestinal angioedema is …

Background Hereditary angioedema with normal C1-inhibitor (HAE-nC1-INH) is a rare
genetic disease. The symptoms can resemble other forms of hereditary angioedema (HAE) …