Estrogens have historically been associated with female reproduction, but work over the last
two decades established that estrogens and their main nuclear receptors (ESR1 and ESR2) …

Lipedema is a painful fat disorder that affects~ 11% of the female population. It is
characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue …

Excessive fat accumulation in the body causes overweight and obesity. To date, research
has confirmed that there are two types of adipose tissue with opposing functions: lipid …

Obesity and its' associated metabolic diseases such as type 2 diabetes and cardiometabolic
disorders are significant health problems confronting many countries. A major driver for …

The main estrogens: estradiol, estrone, and their acyl-esters have been studied essentially
related to their classical estrogenic and pharmacologic functions. However, their main effect …

Postmenopausal women represent an important target population in need of preventative
cardiometabolic approaches. The loss of estrogen following the menopause eliminates …

Estrogen plays a prominent role in regulating and coordinating energy homeostasis
throughout the growth, development, reproduction, and aging of women. Estrogen receptors …

One of the leading causes for the development of adverse metabolic effects, including type 2
diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body …

Abstract Uncoupling protein 1 (UCP1) has been discovered as a possible target for obesity
treatment because of its widespread distribution in the inner mitochondrial membrane of …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are posing great threats to
global health within this century. Studies have suggested that estrogen and estrogen …