Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and
chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non …

Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Targeting cartilage is a promising strategy for the treatment of osteoarthritis, and various
delivery vehicles were developed to assist the therapeutic agents into cartilage. However …

The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear
signaling pathway that is activated to maintain mitochondrial function when there is an …

Background. Osteoarthritis (OA) is a progressive illness that destroys cartilage. Oxidative
stress is a major contributor of OA, while endoplasmic reticulum (ER) stress is the key …

Osteoarthritis (OA) is a common chronic inflammatory disorder. Effective remodeling of
inflammatory microenvironment in the joint is a promising strategy to prevent OA. However …

Objective: Osteoarthritis (OA) is a degenerative chronic disease that most often occurs in the
knee joint. Studies have shown that some food supplements, such as curcumin and …

Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or
decelerate osteoarthritis progression are still lacking. Omaveloxolone is a semisynthetic …

Osteoarthritis (OA) is an age-related degenerative disease. Oxidative stress (OS) modulates
OA pathogenesis by enhancing chondrocyte apoptosis and extracellular matrix (ECM) …

Osteoarthritis (OA) is driven by chronic low-grade inflammation and subsequent cartilage
degradation. OA is the most prevalent degenerative joint disease worldwide, and its …