Simple Summary Breast cancer research is frequently performed using a variety of models,
including animal models, in an attempt to provide information that can be translated into …

Preclinical studies in rodent models have been a pivotal role in human clinical research, but
many of them fail in the translational process. Spontaneous tumors in pet dogs have the …

Canine mammary tumours (CMTs) are the most common neoplasms in intact bitches, and
few chemotherapeutic options are available for highly invasive and metastatic tumours …

Abstract Background Canine mammary tumours (CMTs) are the most frequent tumours in
intact female dogs and show strong similarities with human breast cancer. In contrast to the …

The heterogeneous nature of human breast cancer (HBC) can still lead to therapy inefficacy
and high lethality, and new therapeutics as well as new spontaneous animal models are …

The Hippo signalling pathway is involved in breast cancer and canine mammary tumour
(CMT). This study sought to evaluate the efficacy of fluvastatin on the Hippo pathway and its …

Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer deaths in
humans (2020) but modeling late-stage human CRC, including high tumor budding and …

The diagnosis of primary and secondary CNS neoplasms of dogs and cats relies on
histologic examination of autopsy or biopsy samples. In addition, many neoplasms must be …

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP
and TAZ as its most important downstream effectors that shuttle between cytoplasma and …

The lack of effective therapeutic modalities for mammary cancer is attributed to side effects
and therapy resistance, necessitating the exploration of alternative treatment options …