The seasons within: a theoretical perspective on photoperiodic entrainment and encoding

C Schmal - Journal of Comparative Physiology A, 2024 - Springer
Circadian clocks are internal timing devices that have evolved as an adaption to the
omnipresent natural 24 h rhythmicity of daylight intensity. Properties of the circadian system …

The physiological and pharmacological significance of the circadian timing of the HPA axis: a mathematical modeling approach

Y Li, L Lu, IP Androulakis - Journal of Pharmaceutical Sciences, 2024 - Elsevier
As a potent endogenous regulator of homeostasis, the circadian time-keeping system
synchronizes internal physiology to periodic changes in the external environment to …

Optimal phase-selective entrainment of heterogeneous oscillator ensembles

B Singhal, IZ Kiss, JS Li - SIAM journal on applied dynamical systems, 2023 - SIAM
We develop a framework to design optimal entrainment signals that entrain an ensemble of
heterogeneous nonlinear oscillators, described by phase models, at desired phases. We …

Light-induced synchronization of the SCN coupled oscillators and implications for entraining the HPA axis

Y Li, IP Androulakis - Frontiers in Endocrinology, 2022 - frontiersin.org
The suprachiasmatic nucleus (SCN) synchronizes the physiological rhythms to the external
light-dark cycle and tunes the dynamics of circadian rhythms to photoperiod fluctuations …

Network structure of the master clock is important for its primary function

C Gu, J Li, J Zhou, H Yang, J Rohling - Frontiers in Physiology, 2021 - frontiersin.org
A master clock located in the suprachiasmatic nucleus (SCN) regulates the circadian rhythm
of physiological and behavioral activities in mammals. The SCN has two main functions in …

Generation and disruption of circadian rhythms in the suprachiasmatic nucleus: a core-shell model

AV Goltsev, EAP Wright… - Journal of Biological …, 2022 - journals.sagepub.com
We focus our research on how the core-shell organization controls behavior of the
suprachiasmatic nucleus (SCN), how the core and shell are synchronized to the …

[HTML][HTML] Heterogeneity of neuronal properties determines the collective behavior of the neurons in the suprachiasmatic nucleus

C Gu, P Wang, T Weng, H Yang… - Mathematical Biosciences …, 2019 - aimspress.com
Circadian rhythms have been observed in behavioral and physiological activities of living
things exposed to the natural 24 h light-darkness cycle. Interestingly, even under constant …

Entrainment range of the suprachiasmatic nucleus affected by the difference in the neuronal amplitudes between the light-sensitive and light-insensitive regions

C Gu, H Yang, Z Ruan - Physical Review E, 2017 - APS
Mammals not only can be synchronized to the natural 24-h light-dark cycle, but also to a
cycle with a non-24-h period. The range of the period of the external cycle, for which the …

Entrainment range affected by the second-order interactions between coupled neuron oscillators in the suprachiasmatic nucleus

W Zheng, C Gu, Y Xu, H Yang - Chaos, Solitons & Fractals, 2023 - Elsevier
Higher-order interactions between coupled oscillators in neural networks exhibit a series of
collective behavior phenomena, especially synchronization, some of which cannot occur in …

Differences in intrinsic amplitudes of neuronal oscillators improve synchronization in the suprachiasmatic nucleus

C Gu, H Yang - Chaos: An Interdisciplinary Journal of Nonlinear …, 2017 - pubs.aip.org
In mammals, a main clock located in the suprachiasmatic nucleus (SCN) regulates the∼ 24
h rhythms of behavioral and physiological activities exposed to a natural 24 light-dark cycle …