Paraoxonase and atherosclerosis
PN Durrington, B Mackness… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …
HDL and arteriosclerosis: beyond reverse cholesterol transport
JR Nofer, B Kehrel, M Fobker, B Levkau, G Assmann… - Atherosclerosis, 2002 - Elsevier
The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol
and the risk of coronary heart disease, the protection of susceptible animals from …
and the risk of coronary heart disease, the protection of susceptible animals from …
Human serum paraoxonase
B Mackness, PN Durrington, MI Mackness - General Pharmacology: The …, 1998 - Elsevier
Human serum paraoxonase (PON1) is a Ca 2+-dependent 45-kDa glycoprotein that is
associated with high density lipoprotein (HDL). 2. PON1 hydrolyzes organophosphate (OP) …
associated with high density lipoprotein (HDL). 2. PON1 hydrolyzes organophosphate (OP) …
Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?
B Mackness, GK Davies, W Turkie, E Lee… - … , and vascular biology, 2001 - Am Heart Assoc
Human serum paraoxonase (PON1) hydrolyzes oxidized lipids in low density lipoprotein
(LDL) and could therefore retard the development of atherosclerosis. In keeping with this …
(LDL) and could therefore retard the development of atherosclerosis. In keeping with this …
Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative …
B Mackness, MI Mackness, S Arrol, W Turkie… - FEBS …, 1998 - Wiley Online Library
Human serum paraoxonase (PON1) associated with high density lipoprotein (HDL) has
been postulated to have a role in protecting low density lipoprotein (LDL) against oxidative …
been postulated to have a role in protecting low density lipoprotein (LDL) against oxidative …
Human Serum Paraoxonase/Arylesterase's Retained Hydrophobic N-Terminal Leader Sequence Associates With HDLs by Binding Phospholipids: Apolipoprotein AI …
RC Sorenson, CL Bisgaier, M Aviram… - … , and vascular biology, 1999 - Am Heart Assoc
In serum, human paraoxonase/arylesterase (PON1) is found exclusively associated with
high density lipoprotein (HDL) and contributes to its antiatherogenic properties by inhibiting …
high density lipoprotein (HDL) and contributes to its antiatherogenic properties by inhibiting …
Atheroprotective mechanisms of HDL
O Stein, Y Stein - Atherosclerosis, 1999 - Elsevier
The aim of this review was to bring together results obtained from studies on different
aspects of HDL as related to CHD and atherosclerosis. As atherosclerosis is a multistep …
aspects of HDL as related to CHD and atherosclerosis. As atherosclerosis is a multistep …
Promoter Polymorphisms of Human Paraoxonase PON1 Gene and Serum Paraoxonase Activities and Concentrations
I Leviev, RW James - Arteriosclerosis, thrombosis, and vascular …, 2000 - Am Heart Assoc
Paraoxonase (PON) is a serum enzyme with a wide species distribution. It protects
lipoproteins from toxic oxidative modifications and is an antiatherogenic mechanism of major …
lipoproteins from toxic oxidative modifications and is an antiatherogenic mechanism of major …
Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high affinity, saturable, desorption mechanism
S Deakin, I Leviev, M Gomaraschi, L Calabresi… - Journal of Biological …, 2002 - ASBMB
Paraoxonase-1 (PON1) is a high density lipoprotein (HDL)-associated serum enzyme that
protects low density lipoproteins from oxidative modifications. There is a relative lack of …
protects low density lipoproteins from oxidative modifications. There is a relative lack of …
Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
LG Costa, TB Cole, GP Jarvik… - Annual Review of …, 2003 - annualreviews.org
This review focuses on the functional genomics of the human paraoxonase (PON1)
polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) …
polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) …