Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

The 1952 observation of host-induced non-hereditary variation in bacteriophages by
Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that …

DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Many complex cellular events depend on multiprotein complexes known as molecular
machines to efficiently couple the energy derived from adenosine triphosphate hydrolysis to …

This article outlines the protein modules that target methylated lysine histone marks and
5mC DNA marks, and the molecular principles underlying recognition. The article focuses …

The recently characterized mammalian writer (methyltransferase) and eraser (demethylase)
of the DNA N6-methyladenine (N6mA) methyl mark act on single-stranded (ss) and …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), as an epigenetic regulator,
plays important roles in the tumorigenesis and cancer progression. KiSS1 functions as a …

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified
cytosine—5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5 …

R. DpnI consists of N-terminal catalytic and C-terminal winged helix domains that are
separately specific for the Gm6ATC sequences in Dam-methylated DNA. Here we present a …

There have been very few reports on protein domains that specifically recognize sulfur. Here
we present the crystal structure of the sulfur-binding domain (SBD) from the DNA …