The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Brain tumors represent the second most frequent etiology in patients with focal seizure onset
before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain …

Gliomas form a heterogeneous group of tumors of the central nervous system (CNS) and are
traditionally classified based on histologic type and malignancy grade. Most gliomas, the …

Epileptogenic tumors affecting children and young adults are a morphologically diverse
collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or …

Epilepsy in neuroepithelial tumors is highly prevalent. Neurogliomas (dysembryoplastic
neuroepitheliomas [DNETs] and gangliogliomas) have a seizure incidence of 80–100%, low …

BACKGROUND Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous
system and are commonly associated with chronic seizures. To date, only case reports and …

Every fourth patient submitted to epilepsy surgery suffers from a brain tumor.
Microscopically, these neoplasms present with a wide-ranging spectrum of glial or glio …

The term long‐term epilepsy associated tumor (LEAT) encompasses lesions identified in
patients investigated for long histories (often 2 years or more) of drug‐resistant epilepsy …

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a
comprehensive account of the pathological findings in neurological disease, their biological …