Food-drug interactions frequently hamper oral drug development due to various
physicochemical, physiological and formulation-dependent mechanisms. This has …

As a drug advances through the late stages of clinical development, formulation changes
are common to meet clinical, manufacturing, and/or business needs. Since some formulation …

The incorporation of counterions into amorphous solid dispersions (ASDs) has been proven
to be effective for improving the dissolution rates of ionizable drugs in ASDs. In this work, the …

Extemporaneous preparation (EP) formulation is an attractive strategy to accelerate the
formulation development of new chemical entities for first entry into human study. In this …

The incorporation of a counterion into an amorphous solid dispersion (ASD) has been
proven to be an attractive strategy to improve the drug dissolution rate. In this work, the …

The TIM-1 gastrointestinal model is one of the most advanced in vitro systems currently
available for biorelevant dissolution testing. This technology, the initial version of which was …

The use of in vitro-in vivo correlation (IVIVC) for extended release oral dosage forms is an
important technique that can avoid potential clinical studies. IVIVC has been a topic of …

It is desirable but remains challenging to develop high drug load amorphous solid
dispersions (ASDs) without compromising their quality attributes and bio-performance. In …

Safety and efficacy are the most critical factors for the development of modern medications.
For oral drugs, evaluating drug exposure under various conditions is one of the most …

Dynamic in vitro absorption systems and mechanistic absorption modeling via PBPK have
both shown promise in predicting human oral absorption, although these efforts have been …