Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Mass spectrometry imaging with high resolution in mass and space

A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

A concise review of mass spectrometry imaging

ERA van Hove, DF Smith, RMA Heeren - Journal of chromatography A, 2010 - Elsevier
Mass spectrometric imaging allows the investigation of the spatial distribution of molecules
at complex surfaces. The combination of molecular speciation with local analysis renders a …

Mass spectrometry imaging for clinical research–latest developments, applications, and current limitations

PM Vaysse, RMA Heeren, T Porta, B Balluff - Analyst, 2017 - pubs.rsc.org
Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

Adding a new separation dimension to MS and LC–MS: what is the utility of ion mobility spectrometry?

V d'Atri, T Causon, O Hernandez‐Alba… - Journal of separation …, 2018 - Wiley Online Library
Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Imaging mass spectrometry: instrumentation, applications, and combination with other visualization techniques

A Bodzon‐Kulakowska, P Suder - Mass spectrometry reviews, 2016 - Wiley Online Library
Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It
has unique ability to identify structures and to unravel molecular changes that occur in the …

Recent developments in ion mobility spectrometry

H Borsdorf, T Mayer, M Zarejousheghani… - Applied spectroscopy …, 2011 - Taylor & Francis
The general principles and technical implementations of traditional time-of-flight ion mobility
spectrometers and analyzers with field-dependent mobilities were reviewed in our last …

Imaging mass spectrometry for lipidomics

N Goto-Inoue, T Hayasaka, N Zaima, M Setou - Biochimica et Biophysica …, 2011 - Elsevier
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful tool
that enables the simultaneous detection and identification of biomolecules in analytes …

Peptide and protein imaging mass spectrometry in cancer research

LA McDonnell, GL Corthals, SM Willems… - Journal of …, 2010 - Elsevier
MALDI mass spectrometry is able to acquire protein profiles directly from tissue that can
describe the levels of hundreds of distinct proteins. MALDI imaging MS can simultaneously …