The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

PC Lo, MS Rodríguez-Morgade, RK Pandey… - Chemical Society …, 2020 - pubs.rsc.org
Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of
photosensitisers for photodynamic therapy of cancer. Several derivatives are at various …

Mitochondria‐Targeting Phthalocyanines and Porphyrins for Enhanced Photodynamic Tumor Therapy

M Li, K Zheng, X Liu - ChemistrySelect, 2023 - Wiley Online Library
Photodynamic therapy (PDT) is a promising non‐invasive treatment modality for tumors.
However, the lack of attack targets in tumor cells greatly affects the antitumor efficiency of …

Positively charged styryl pyridine substituted Zn (II) phthalocyanines for photodynamic therapy and photoantimicrobial chemotherapy: effect of the number of charges

A Magadla, B Babu, J Mack, T Nyokong - Dalton Transactions, 2021 - pubs.rsc.org
Cationic Zn phthalocyanine complexes were synthesized using Knoevenagel reaction
starting from a Zn (II) tetrakis (2-formylphenoxy) phthalocyanine (1) to form Zn (II) tetrakis (1 …

Dual effect of light and ultrasound for efficient singlet oxygen generation with novel diaxial silicon phthalocyanine sensitizer

GG Köse, A Erdoğmuş - Photochemistry and Photobiology, 2024 - Wiley Online Library
To treat a life‐threatening disease like cancer, photodynamic therapy (PDT) and
sonodynamic therapy (SDT) methods were combined into sono‐photodynamic therapy …

[HTML][HTML] Enhanced mitochondria destruction on MCF-7 and HeLa cell lines in vitro using triphenyl-phosphonium-labelled phthalocyanines in ultrasound-assisted …

LC Nene, A Magadla, T Nyokong - Journal of Photochemistry and …, 2022 - Elsevier
This work reports on the reactive oxygen species (ROS) generation and the therapeutic
activities of new triphenyl-phosphonium-labelled phthalocyanines (Pcs), the 2, 9, 16, 23 …

Synthesis and photodynamic activities of novel silicon (IV) phthalocyanines axially substituted with water soluble groups against HeLa cancer cell line

M Göksel, M Durmuş, Z Biyiklioglu - Dalton Transactions, 2021 - pubs.rsc.org
In this study, compounds 1 and 2, and their silicon (IV) phthalocyanine (SiPc) derivatives 3
and 4, which bear these ligands as substituents on the axial positions were synthesized …

Development of AB3-Type Novel Phthalocyanine and Porphyrin Photosensitizers Conjugated with Triphenylphosphonium for Higher Photodynamic Efficacy

E Onal, O Tuncel, I Erdoğan Vatansever… - ACS …, 2022 - ACS Publications
There are a number of lipophilic cations that can be chosen; the triphenylphosphonium
(TPP) ion is particularly unique for mitochondrion targeting, mainly due to its simplicity in …

Synthesis of both peripheral and non-peripheral substituted metal-free phthalocyanines and characterization

G Ekineker, M Göksel - Tetrahedron, 2020 - Elsevier
The phthalocyanines were synthesized via phthalonitrile cyclotetramerization in the
presence of lithium metal and/or zinc acetate in this study. New symmetric peripheral-tetra …

Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action

G Xu, X Xu, J Liu, Q Jia, C Ke, H Zhang, C Xu… - …, 2022 - Wiley Online Library
A series of mitochondria‐targeted triphenylphosphonium conjugated C‐3 modified betulin
were synthesized and evaluated against tumor cells. As a result, a new derivative 13 i, the …

Multicomponent Crystals of Phthalocyanines–A Possibility of Fine-Tuning Properties

DO Oluwole, NB Báthori - Colorants, 2023 - mdpi.com
Phthalocyanines (Pcs) are 18-electron π-conjugated macrocyclic ring systems with proven
activities in diverse fields, including pharmaceuticals and catalysis. These demonstrated …