Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there
might be various different triggering events in the early stages of the disease, they seem to …

As reactive oxygen species (ROS) play critical roles in plants to determine cell fate in various
physiological situations, there is keen interest in the biochemical processes of ROS signal …

Lipids can go through lipid peroxidation, an endogenous chain reaction that consists in the
oxidative degradation of lipids leading to the generation of a wide variety of highly reactive …

Acrolein is a highly toxic agent that may promote the occurrence and development of various
diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main …

The Maillard reaction is a complex series of reactions that involve reducing-sugars and
proteins, giving a multitude of end-products that are known as advanced glycation end …

The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole
animal levels. This review discusses the possible mechanisms by which carnosine may …

Protein carbonylation induced by reactive carbonyl species (RCS) generated by
peroxidation of polyunsaturated fatty acids plays a significant role in the etiology and/or …

The metabolic syndrome is a risk factor that increases the risk for development of renal and
vascular complications. This study addresses the effects of chronic administration of the …