Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

INTRODUCTION MicroRNAs (miRNAs) are short RNAs that direct widespread gene
repression in the cells of humans and other animals. Each miRNA associates with an …

INTRODUCTION MicroRNAs (miRNAs) are a class of highly conserved small regulatory
RNAs. After loading into Argonaute (AGO) proteins, miRNAs promote the degradation and …

Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …

The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

miRNAs are small RNAs that guide Argonaute proteins to specific target mRNAs to repress
their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the …

MicroRNAs (miRNAs) broadly regulate gene expression through association with Argonaute
(Ago), which also protects miRNAs from degradation. However, miRNA stability is known to …