[HTML][HTML] Evolving concepts in NAD+ metabolism
CCS Chini, JD Zeidler, S Kashyap, G Warner, EN Chini - Cell metabolism, 2021 - cell.com
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
Shared TIR enzymatic functions regulate cell death and immunity across the tree of life
In the 20th century, researchers studying animal and plant signaling pathways discovered a
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
protein domain that is shared across diverse innate immune systems: the Toll/interleukin …
[HTML][HTML] Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
degeneration and a therapeutic target for several neurodegenerative conditions. We show …
The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1
Pathological degeneration of axons disrupts neural circuits and represents one of the
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …
hallmarks of neurodegeneration,,–. Sterile alpha and Toll/interleukin-1 receptor motif …
[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
HC Feldman, E Merlini, C Guijas… - Proceedings of the …, 2022 - National Acad Sciences
The nicotinamide adenine dinucleotide hydrolase (NADase) sterile alpha toll/interleukin
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
receptor motif containing-1 (SARM1) acts as a central executioner of programmed axon …
SARM1 is a multi-functional NAD (P) ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
Summary SARM1 is an NAD (P) glycohydrolase and TLR adapter with an essential,
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD …
Molecular innovations in plant TIR-based immunity signaling
A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs
mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of …
mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of …
Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
AJ Bloom, X Mao, A Strickland, Y Sasaki… - Molecular …, 2022 - Springer
Background In response to injury, neurons activate a program of organized axon self-
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …
destruction initiated by the NAD+ hydrolase, SARM1. In healthy neurons SARM1 is …
Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity
X Wang, X Li, G Yu, L Zhang, C Zhang, Y Wang, F Liao… - Cell Research, 2023 - nature.com
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite in cellular processes.
Depletion of NAD+ has been demonstrated to be a prevalent theme in both prokaryotic and …
Depletion of NAD+ has been demonstrated to be a prevalent theme in both prokaryotic and …