Impact of cholesterol metabolism in immune cell function and atherosclerosis

M Aguilar-Ballester, A Herrero-Cervera, Á Vinué… - Nutrients, 2020 - mdpi.com
Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Lipid metabolism in inflammation-related diseases

C Zhang, K Wang, L Yang, R Liu, Y Chu, X Qin, P Yang… - Analyst, 2018 - pubs.rsc.org
There are thousands of lipid species existing in cells, which belong to eight different
categories. Lipids are the essential building blocks of cells. Recent studies have started to …

Targeting human Acyl-CoA: cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

NM Schmidt, PAC Wing, MO Diniz, LJ Pallett… - Nature …, 2021 - nature.com
Determining divergent metabolic requirements of T cells, and the viruses and tumours they
fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA: cholesterol …

Targeting lipid rafts as a strategy against coronavirus

M Sorice, R Misasi, G Riitano, V Manganelli… - Frontiers in Cell and …, 2021 - frontiersin.org
Lipid rafts are functional membrane microdomains containing sphingolipids, including
gangliosides, and cholesterol. These regions are characterized by highly ordered and tightly …

Effects of fatty acids on T cell function: role in atherosclerosis

NA Reilly, E Lutgens, J Kuiper, BT Heijmans… - Nature Reviews …, 2021 - nature.com
T cells are among the most common cell types present in atherosclerotic plaques and are
increasingly being recognized as a central mediator in atherosclerosis development and …

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

HM Al‐kuraishy, NR Hussien… - Immunity …, 2023 - Wiley Online Library
Introduction Covid‐19 is linked with the development of cardio‐metabolic disorders,
including dyslipidemia, dysregulation of high‐density lipoprotein (HDL), and low‐density …

Disrupted lipid metabolism in multiple sclerosis: a role for liver X receptors?

I Pineda-Torra, S Siddique, KE Waddington… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS) is a chronic neurological disease driven by autoimmune,
inflammatory and neurodegenerative processes leading to neuronal demyelination and …

Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) hepatopancreas challenged by Vibrio alginolyticus reveals lipid metabolic disturbance

X Yin, X Zhuang, M Liao, L Huang, Q Cui, C Liu… - Fish & Shellfish …, 2022 - Elsevier
Vibrio alginolyticus is a devastating bacterial pathogen of Pacific white shrimp (Litopenaeus
vannamei), which often causes acute hepatopancreatic necrosis syndrome (AHPNS) and …

HDL in immune-inflammatory responses: implications beyond cardiovascular diseases

F Bonacina, A Pirillo, AL Catapano, GD Norata - Cells, 2021 - mdpi.com
High density lipoproteins (HDL) are heterogeneous particles composed by a vast array of
proteins and lipids, mostly recognized for their cardiovascular (CV) protective effects …

T-cell mechanobiology: force sensation, potentiation, and translation

DL Harrison, Y Fang, J Huang - Frontiers in physics, 2019 - frontiersin.org
AT cell is a sensitive self-referential mechanical sensor. Mechanical forces influence the
recognition, activation, differentiation, and function throughout the lifetime of a T cell. T cells …