By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Organoids have immense potential as ex vivo disease models for drug discovery and
personalized drug screening. Dynamic changes in individual organoid morphology, number …

Confocal Raman spectral imaging (RSI) enables high-content, label-free visualization of a
wide range of molecules in biological specimens without sample preparation. However …

An organoid is a miniaturized and simplified in vitro model with a similar structure and
function to a real organ. In recent years, the use of organoids has increased explosively in …

Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental
research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a …

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and
functional features of specific organs. Because of these characteristics, organoids have …

We demonstrate the use of Bessel beams for side illumination slit-scanning Raman imaging
for label-free and hyperspectral analysis of cell spheroids. The background elimination by …

Raman confocal microscopes have been used to visualize the distribution of small molecule
drugs within different subcellular compartments. This visualization allows the discovery …

Cell spheroids offer alternative in vitro cell models to monolayer cultured cells because they
express complexities similar to those of in vivo tissues, such as cellular responses to drugs …