Ischemic stroke is an acute cerebrovascular disease characterized by sudden interruption of
blood flow in a certain part of the brain, leading to serious disability and death. At present …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

Inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α) is the most
prominent and evolutionarily conserved endoplasmic reticulum (ER) membrane protein …

Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …

Protein folding in the cell is mediated by an extensive network of> 1,000 chaperones, quality
control factors, and trafficking mechanisms collectively termed the proteostasis network …

Classically, the unfolded protein response (UPR) safeguards secretory pathway
proteostasis. The most ancient arm of the UPR, the IRE1-activated spliced X-box binding …

Previous investigations have increased the knowledge about the pathological processes of
inflammatory bowel diseases. Besides the complex organization of immune reactions, the …

Intracellular procollagen folding begins at the protein's C-terminal propeptide (C-Pro)
domain, which initiates triple-helix assembly and defines the composition and chain register …

The collagenopathies are a diverse group of diseases caused primarily by mutations in
collagen genes. The resulting disruptions in collagen biogenesis can impair development …

The sequence space accessible to evolving proteins can be enhanced by cellular
chaperones that assist biophysically defective clients in navigating complex folding …