Complex diseases such as neurodegenerative disorders and cancer constitute a growing
public health problem due to the rising incidence and lack in effective therapies. Since …

Phospholipid scramblases (PLSCRs) that catalyze rapid mixing of plasma membrane lipids
result in surface exposure of phosphatidyl serine (PS), a lipid normally residing to the inner …

The natural compound plumbagin has a wide range of pharmacological and potential
therapeutic activities, although its role in neuroretina degeneration is unknown. Here we …

Melosira nummuloides is a microalga with a nutritionally favorable polyunsaturated fatty acid
profile. In the present study, M. nummuloides ethanol extract (MNE) was administered to …

Loss of retinal neurons may precede clinical signs of diabetic retinopathy (DR). We studied
for the first time the effects of hyperglycemia on the visual system of the fruit fly Drosophila …

Chromolaena tacotana is a source of flavonoids with antiproliferative properties in human
breast cancer cells, the most common neoplasm diagnosed in patients worldwide. Until now …

Aberrant production of reactive oxygen species (ROS) is a common feature of damaged
retinal neurons in diabetic retinopathy, and antioxidants may exert both preventive and …

Piper eriopodon is one of the Piper species found in the Sierra Nevada de Santa Marta, and
the species has been reported with different compositions of their essential oils (EO). In this …

Calycosin is reportedly evidenced with pharmacologically treating bone cells. However, the
comprehensive anti-osteosarcoma (OS) mechanisms of calycosin have not been uncovered …

Schiff base compounds and their metal complexes have become important synthetic organic
drugs due to their extensive biological activities, which include anticancer, antibacterial and …