Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

The human brain displays a rich repertoire of states that emerge from the microscopic
interactions of cortical and subcortical neurons. Difficulties inherent within large-scale …

Recordings of extracellular electrical, and later also magnetic, brain signals have been the
dominant technique for measuring brain activity for decades. The interpretation of such …

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …

What physiological role does a slow hyperpolarization‐activated ion channel with mixed
cation selectivity play in the fast world of neuronal action potentials that are driven by …

Neurons and glial cells are endowed with membranes that express a rich repertoire of ion
channels, transporters, and receptors. The constant flux of ions across the neuronal and glial …

Understanding the brain requires studying its multiscale interactions from molecules to
networks. The increasing availability of large-scale datasets detailing brain circuit …

Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …

Dendrites of cortical pyramidal cells are densely populated by hyperpolarization-activated
cyclic nucleotide-gated (HCN) channels, aka I h channels. I h channels are targeted by …