Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malaria
Background PfHRP2-based rapid diagnostic tests (RDTs), based on the recognition of the
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …
Plasmodium falciparum histidine-rich protein 2, are currently the most used tests in malaria …
Factors affecting the performance of HRP2-based malaria rapid diagnostic tests
The recent COVID-19 pandemic has profoundly impacted global malaria elimination
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
programs, resulting in a sharp increase in malaria morbidity and mortality. To reduce this …
A cross-sectional study of the prevalence, density, and risk factors associated with malaria transmission in urban communities of Ibadan, Southwestern Nigeria
Background Malaria is a severe global public health challenge that causes significant
morbidity and mortality worldwide, particularly in sub-Saharan Africa. This study was …
morbidity and mortality worldwide, particularly in sub-Saharan Africa. This study was …
Residual malaria in Jazan region, southwestern Saudi Arabia: the situation, challenges and climatic drivers of autochthonous malaria
Abstract Background Saudi Arabia and Yemen are the only two countries in the Arabian
Peninsula that are yet to achieve malaria elimination. Over the past two decades, the …
Peninsula that are yet to achieve malaria elimination. Over the past two decades, the …
Identification of Plasmodium falciparum isolates lacking histidine-rich protein 2 and 3 in Eritrea
M Menegon, M L'Episcopia, AM Nurahmed… - Infection, Genetics and …, 2017 - Elsevier
The histidine-rich protein 2 of Plasmodium falciparum is the most common malaria antigen
targeted by rapid diagnostic tests for the specific diagnosis of P. falciparum. Recently, pfhrp2 …
targeted by rapid diagnostic tests for the specific diagnosis of P. falciparum. Recently, pfhrp2 …
Bead-based immunoassay allows sub-picogram detection of histidine-rich protein 2 from Plasmodium falciparum and estimates reliability of malaria rapid diagnostic …
E Rogier, M Plucinski, N Lucchi, K Mace, M Chang… - PLoS …, 2017 - journals.plos.org
Detection of histidine-rich protein 2 (HRP2) from the malaria parasite Plasmodium
falciparum provides evidence for active or recent infection, and is utilized for both diagnostic …
falciparum provides evidence for active or recent infection, and is utilized for both diagnostic …
Impact of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions on malaria control worldwide: a systematic review and meta-analysis
Background Deletion of pfhrp2 and/or pfhrp3 genes cause false negatives in malaria rapid
diagnostic test (RDT) and threating malaria control strategies. This systematic review aims to …
diagnostic test (RDT) and threating malaria control strategies. This systematic review aims to …
Genetic diversity of Plasmodium falciparum and genetic profile in children affected by uncomplicated malaria in Cameroon
TN Metoh, JH Chen, P Fon-Gah, X Zhou… - Malaria Journal, 2020 - Springer
Background Malaria is a major public health problem in Cameroon. The study of the genetic
diversity within parasite population is essential for understanding the mechanism underlying …
diversity within parasite population is essential for understanding the mechanism underlying …
Spatiotemporal dynamics of Plasmodium falciparum histidine-rich protein 2 and 3 deletions in Peru
Peru was the first country where pfhrp2 and pfhrp3 gene deletions were detected despite the
fact that rapid diagnostics tests are not commonly used for confirmatory malaria diagnosis …
fact that rapid diagnostics tests are not commonly used for confirmatory malaria diagnosis …
Deletions of the Plasmodium falciparum histidine-rich protein 2/3 genes are common in field isolates from north-eastern Tanzania
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3 (pfhrp2/3) genes
have been reported in several parts of the world. These deletions are known to compromise …
have been reported in several parts of the world. These deletions are known to compromise …