Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …

Mechanisms of bile acid–induced (BA-induced) liver injury in cholestasis are controversial,
limiting development of new therapies. We examined how BAs initiate liver injury using …

Introduction: Cholestasis is a reduction in bile flow that occurs during numerous pathologies.
Blockage of the biliary tracts results in hepatic accumulation of bile acids or their conjugate …

Organochlorine pesticides (OCPs) can persistently accumulate in body and threaten human
health. Bile acids and intestinal microbial metabolism have emerged as important signaling …

The cell-toxic bile salt glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholic
acid (TCDCA) are responsible for hepatocyte demise in cholestatic liver diseases, while …

Bile acids have an important role in the growth and sterol metabolism of shrimp. The aim of
this study was to elucidate the effects of bile acids supplementation in the low fishmeal diets …

Ethnopharmacological relevance Urolithin A is an active metabolite of plant polyphenol
ellagic acid generated by intestinal flora, which is derived from strawberry or traditional anti …

Cholestasis is a result of obstruction of the biliary tracts. It is a common cause of liver
pathology after exposure to toxic xenobiotics and during numerous other liver diseases …

Abstract Background Cyp2c70-/-mice with a human-like bile acid (BA) composition display
features of neonatal cholestasis. We assessed whether perinatal ursodeoxycholic acid …

Isoniazid is the first-line medication in the prevention and treatment of tuberculosis. Isoniazid
is known to have a biphasic effect on the inhibition–induction of CYP2E1 and is also …