Thirty per cent of all colorectal tumours develop in the rectum. The location of the rectum
within the bony pelvis and its proximity to vital structures presents significant therapeutic …

The goal of treatment for early stage rectal cancer is to optimize oncologic control while
minimizing the long-term impact of treatment on quality of life. The standard of care treatment …

Local recurrence after resection for rectal cancer remains common despite growing
acceptance that inadequate local excision may be implicated. In a prospective study of 190 …

PURPOSE: Transanal endoscopic microsurgery provides a minimally invasive alternative to
radical surgery for excision of benign and malignant rectal tumors. The purpose of this study …

Background Transanal endoscopic microsurgery (TEM) allows locally complete resection of
early rectal cancer as an alternative to conventional radical surgery. In case of unfavourable …

Purpose Standard of care treatment for most stage I rectal cancers is total mesorectal
excision (TME). Given the morbidity associated with TME, local excision (LE) for early-stage …

Rectal adenomas and cancers occur frequently. Small adenomas can be removed
colonoscopically, whereas larger polyps are removed via conventional transanal excision …

Background Organ-preserving treatment for early-stage rectal cancer may avoid the
substantial perioperative morbidity and functional sequelae associated with total mesorectal …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …

Background Peritoneal entry during transanal endoscopic microsurgery (TEM) can usually
be managed transanally with full-thickness suture closure by experienced operators. The …