Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Hydrophilic polymeric networks that are capable of imbibing huge volumes of water and
undergoing swelling and shrinkage suitably to facilitate controlled drug-release are called …

Bioprinting offers a highly-automated and advanced manufacturing platform that facilitates
the deposition of bio-inks (living cells, biomaterials and growth factors) in a scalable and …

Patient-derived tumor organoids (PDOs) are a highly promising preclinical model that
recapitulates the histology, gene expression, and drug response of the donor patient tumor …

Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Besides molecular and phenotypic variations observed in cancer cells, intratumoral
heterogeneity also occurs in the tumor microenvironment. Correlative stiffness maps of …

The identification of stem-cell-like cancer cells through conventional methods that depend
on stem cell markers is often unreliable. We developed a mechanical method for selecting …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …