Reaction coordinates are integral to several classic rate theories that can (a) predict kinetic
trends across conditions and homologous reactions,(b) extract activation parameters with a …

Some of the rate theories that are most useful for modeling biological processes are
reviewed. By delving into some of the details and subtleties in the development of the …

We present an overview of the current status of transition-state theory and its
generalizations. We emphasize (i) recent improvements in available methodology for …

A brief history is presented, outlining the development of rate theory during the past century.
Starting from Arrhenius [Z. Phys. Chem. 4, 226 (1889)], we follow especially the formulation …

We present accurate fully quantum calculations of thermal rate constants for a symmetric
double well system coupled to a dissipative bath. The calculations are performed using the …

The introduction of a low dimensional description is an important first step towards
understanding the dynamics of complex systems. When can a multidimensional activated …

A complete description of protein folding kinetics must account for the microscopic dynamics
of the polypeptide chain. The relaxation of a free polymer is well described by Langevin …

The Kramers problem in periodic potentials is solved separating the intrawell and interwell
dynamics. Both the jump rate and the probability distribution of the jump lengths are …

The theoretical framework for describing solvent effects on solution phase reactions is
summarized. When possible, the results are related to experiments involving geometric …

This perspective focuses on conceptual and computational aspects of the potential energy
landscape framework. It has two objectives: first to summarise some key developments of …