Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal
cognitive performance. Despite the fact that many have studied how ACh affects neuronal …

In the 1920s, tobacco companies created a marketing campaign for what would one day be
their most profitable series of products: mentholated tobacco cigarettes. Menthol provides …

Cigarette smoking is currently the leading cause of preventable deaths and disability
throughout the world, being responsible for about five million premature deaths/year …

Smoking is the most important preventable cause of morbidity and mortality worldwide.
Recent genome-wide association studies highlighted a human haplotype on chromosome …

Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system,
originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors …

The nicotinic acetylcholine receptors (nAChRs) and the 5-HT 3 receptors (5-HT 3 Rs) are
cation-selective members of the pentameric ligand-gated ion channels (pLGICs), which are …

Nicotine, the principal reinforcing compound in tobacco, acts in the brain by activating
neuronal nicotinic acetylcholine receptors (nAChRs). This review summarizes our current …

Neuronal nicotinic acetylcholine receptors (nAChRs) containing the α5 subunit modulate
nicotine consumption, and the human CHRNA5 rs16969968 polymorphism, causing the …