B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …

Observational studies and stand-alone trials indicate that patients with follicular lymphoma
(FL) who experience disease progression within 24 months of front-line …

Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells
undergo somatic mutation and selection and eventual differentiation into memory B cells or …

Abstract FDG‐PET/CT is the current state‐of‐the‐art imaging in lymphoma and plays a
central role in treatment decisions. At diagnosis, accurate staging is crucial for appropriate …

The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …

Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of
transformation to more aggressive histology over time. Recurrent mutations associated with …

Epigenetic regulation is a novel approach to cancer treatment. Inhibition of enhancer of
zeste homolog 2 (EZH2) is a method to provide targeted epigenetic regulation. Tazemetostat …

Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival
with macrophages playing a controversial role. In the present study, using FL primary …

Heterozygous inactivating mutations of the KMT2D methyltransferase and the CREBBP
acetyltransferase are among the most common genetic alterations in B cell lymphoma and …