Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Infective diseases have become health threat of a global proportion due to appearance and
spread of microorganisms resistant to majority of therapeutics currently used for their …

Introduction Metabolomics is a fast growing technology that has effectively contributed to
many plant‐related sciences and drug discovery. Objective To use the non‐targeted …

A metal-free room temperature decarboxylative cross-coupling between cinnamic acids and
arylsulfonyl hydrazides has been realized for the first time for the synthesis of (E)-vinyl …

Thioyl and sulfonyl radicals are usually produced from various thiols and sulfonyl derivatives
in high efficiency by single-electron-transfer (SET) oxidation. The generated sulfur …

Nitriles have broad applications in medicinal chemistry, with more than 60 small molecule
drugs on the market containing the cyano functional group. In addition to the well-known …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

Decarboxylative cross-coupling reactions of cinnamic acids with sulfonylhydrazides were
explored using oxygen as the sole terminal oxidant, realizing a conceptually novel …

A stereoselective synthesis of (E)-vinyl sulfones has been developed via electrochemical
oxidative N–S bond cleavage of aromatic sulfonylhydrazides, followed by cross-coupling …

An electrooxidative direct difunctionalization of internal alkynes with sulfonyl hydrazides has
been developed for the construction of sulfonated enethers. In this transformation, metal …