2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in …

PK Whelton, RM Carey, WS Aronow, DE Casey… - Journal of the American …, 2018 - jacc.org
As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Alterations in endothelial nitric oxide synthase activity and their relevance to blood pressure

T Suvorava, S Metry, S Pick, G Kojda - Biochemical pharmacology, 2022 - Elsevier
Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway

N Liu, L Mei, X Fan, C Tang, X Ji, X Hu, W Shi, Y Qian… - Cancer Letters, 2016 - Elsevier
Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers,
however, the underlying mechanism governing stemness of CSC remains unknown. Herein …

Exogenous NO therapy for the treatment and prevention of atherosclerosis

T Gori - International Journal of Molecular Sciences, 2020 - mdpi.com
Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …

New insights on the beneficial effects of the probiotic kefir on vascular dysfunction in cardiovascular and neurodegenerative diseases

EC Vasquez, R Aires, AMM Ton… - Current Pharmaceutical …, 2020 - ingentaconnect.com
The mechanisms responsible for cardiovascular and neurodegenerative diseases have
been the focus of experimental and clinical studies for decades. The relationship between …

Coadjuvants in the diabetic complications: nutraceuticals and drugs with pleiotropic effects

TMC Pereira, FS Pimenta, ML Porto, MP Baldo… - International Journal of …, 2016 - mdpi.com
Because diabetes mellitus (DM) is a multifactorial metabolic disease, its prevention and
treatment has been a constant challenge for basic and clinical investigators focused on …

Bisphenol A contamination in infant rats: Molecular, structural, and physiological cardiovascular changes and the protective role of kefir

AGF Friques, FDN Santos, DB Angeli, FAC Silva… - The Journal of …, 2020 - Elsevier
The effects of bisphenol A (BPA) contamination on the cardiovascular function still are not
clear. Here, we evaluated the vascular effects of BPA and the protective actions of kefir in …

[HTML][HTML] Boosting nitric oxide in stress and respiratory infection: potential relevance for asthma and COVID-19

T Ritz, ML Salsman, DA Young, AR Lippert… - Brain, behavior, & …, 2021 - Elsevier
Nitric oxide (NO) is a ubiquitous signaling molecule that is critical for supporting a plethora of
processes in biological organisms. Among these, its role in the innate immune system as a …

Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism

C Wang, H Zhang, F Wang, J Guo, J Yuan, G Hou… - The Aging …, 2024 - Taylor & Francis
Purpose Although several reviews have evaluated the use of PDE5 inhibitors (PDE5i) for
treating erectile dysfunction (ED), their specific use in middle-aged and old patients has not …

Celosins inhibit atherosclerosis in ApoE-/-mice and promote autophagy flow

Y Tang, H Wu, B Shao, Y Wang, C Liu, M Guo - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Semen celosiae is a traditional Chinese medicine for
purging hepatic pathogenic fire and removing nebula to improve eyesight, treating …