Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics
Gene editing has great potential in treating diseases caused by well-characterized
molecular alterations. The introduction of clustered regularly interspaced short palindromic …
molecular alterations. The introduction of clustered regularly interspaced short palindromic …
JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles
JA Castro-Mondragon, R Riudavets-Puig… - Nucleic acids …, 2022 - academic.oup.com
Abstract JASPAR (http://jaspar. genereg. net/) is an open-access database containing
manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six …
manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six …
CARM1 arginine methyltransferase as a therapeutic target for cancer
M Santos, JW Hwang, MT Bedford - Journal of Biological Chemistry, 2023 - ASBMB
Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …
[HTML][HTML] PKCα/ZFP64/CSF1 axis resets the tumor microenvironment and fuels anti-PD1 resistance in hepatocellular carcinoma
CY Wei, MX Zhu, PF Zhang, XY Huang, JK Wan… - Journal of …, 2022 - Elsevier
Background & Aims Despite remarkable advances in treatment, most patients with
hepatocellular carcinoma (HCC) respond poorly to anti-programmed cell death 1 (anti-PD1) …
hepatocellular carcinoma (HCC) respond poorly to anti-programmed cell death 1 (anti-PD1) …
BRD8 maintains glioblastoma by epigenetic reprogramming of the p53 network
Inhibition of the tumour suppressive function of p53 (encoded by TP53) is paramount for
cancer development in humans. However, p53 remains unmutated in the majority of cases …
cancer development in humans. However, p53 remains unmutated in the majority of cases …
ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation
The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the …
[HTML][HTML] ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
The transformed state in acute leukemia requires gene regulatory programs involving
transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D …
transcription factors and chromatin modulators. Here, we uncover an IRF8-MEF2D …
ZNF410 uniquely activates the NuRD component CHD4 to silence fetal hemoglobin expression
Metazoan transcription factors typically regulate large numbers of genes. Here we identify
via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in …
via a CRISPR-Cas9 genetic screen ZNF410, a pentadactyl DNA-binding protein that in …
ZNF410 represses fetal globin by singular control of CHD4
Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-
hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR …
hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR …
TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
GN Zhao, ZW Tian, T Tian, ZP Zhu, WJ Zhao, H Tian… - Cell metabolism, 2021 - cell.com
Obesity is characterized by the excessive accumulation of the white adipose tissue (WAT),
but healthy expansion of WAT via adipocyte hyperplasia can offset the negative metabolic …
but healthy expansion of WAT via adipocyte hyperplasia can offset the negative metabolic …