Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …

Metabolic reprogramming is a hallmark of activated T cells. The switch from oxidative
phosphorylation to aerobic glycolysis provides energy and intermediary metabolites for the …

Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Psoriasis is a frequent chronic inflammatory skin disease, nowadays considered a major
global health problem. Several new drugs, targeting the IL-23/IL-17A pathway, have been …

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While
the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL …

The specific regulation of cellular metabolic processes is of major importance for directing
immune cell differentiation and function. We review recent evidence indicating that changes …

CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They
are also involved in autoimmunity, asthma, and allergic responses as well as in tumor …

T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression
of retinoic acid-receptor (RAR)-related orphan receptor (ROR) γt transcription factor …

Allergic diseases are on the rise in the Western world and well-known allergy-protecting and-
driving factors such as microbial and dietary exposure, pollution and smoking mediate their …