Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

D Parama, M Boruah, K Yachna, V Rana, K Banik… - Life sciences, 2020 - Elsevier
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Anticancer steroids: linking natural and semi-synthetic compounds

JAR Salvador, JFS Carvalho, MAC Neves… - Natural product …, 2013 - pubs.rsc.org
Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Current status on development of steroids as anticancer agents

A Gupta, BS Kumar, AS Negi - The Journal of steroid biochemistry and …, 2013 - Elsevier
Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …

A simple and versatile method for the formation of acetals/ketals using trace conventional acids

JL Dong, LSH Yu, JW Xie - ACS omega, 2018 - ACS Publications
An important and surprising finding that the acetalization and ketalization of aldehydes and
ketones with alcohols, respectively, proceed smoothly in the presence of 0.1 mol% acid …

[HTML][HTML] Dioscorea bulbifera L.(Dioscoreaceae): A review of its ethnobotany, pharmacology and conservation needs

BB Kundu, K Vanni, A Farheen, P Jha… - South African journal of …, 2021 - Elsevier
The use of medicinal plants by nutraceutical, cosmeceutical and pharmaceutical industries
is gaining more attention around the globe. Dioscorea bulbifera L.(Family: Dioscoreaceae) …

Diosgenin, a steroid saponin constituent of yams and fenugreek: emerging evidence for applications in medicine

J Raju, CV Rao - Bioactive compounds in phytomedicine, 2012 - books.google.com
Phytochemicals found in foods and spices are progressively gaining popularity over
conventional synthetic drugs mainly because they act via multiple molecular targets that …

Diosgenin a steroidal compound: An emerging way to cancer management

P Arya, P Kumar - Journal of Food Biochemistry, 2021 - Wiley Online Library
To endure respective research for cancer via common food ingredients has become more
prominent with preferably minuscule toxicity. Spices are emerging as a new source of …

Synthesis and biological evaluation of novel 3-O-tethered triazoles of diosgenin as potent antiproliferative agents

Y Mohammad, KM Fazili, KA Bhat, T Ara - Steroids, 2017 - Elsevier
Diosgenin, a promising anticancer steroidal sapogenin, was isolated from Dioscorea
deltoidea. Keeping its stereochemistry rich architecture intact, a scheme for the synthesis of …

Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells

H Torres-Moreno, MC Marcotullio, C Velázquez, F Ianni… - Steroids, 2020 - Elsevier
Chemical studies on Ibervillea sonorae (S. Watson) Greene root led to isolation and
chemical characterization of diverse cucurbitacin triterpenoid compounds such as kinoin A …

Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin

AA Hamid, M Hasanain, A Singh, B Bhukya… - Steroids, 2014 - Elsevier
Diosgenin has been modified to furostane derivatives after opening the F-spiroacetal ring.
The aldehyde group at C26 in derivative 8 was unexpectedly transformed to the ketone 9 …