Gliomas form a heterogeneous group of tumors of the central nervous system (CNS) and are
traditionally classified based on histologic type and malignancy grade. Most gliomas, the …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Morbidity and mortality associated with pediatric malignant primary brain tumors remain high
in the absence of effective therapies. Macrophage-mediated phagocytosis of tumor cells via …

Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays
considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting …

Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …

Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma,
leukemia, and other cancers. Although mutant IDH inhibitors are effective against leukemia …

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-
option is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial …

The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Glial fibrillary acidic protein (GFAP)-positive astrocytes (type B cells) in the subventricular
zone (SVZ) generate large numbers of new neurons in the adult brain. SVZ stem cells can …