Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Mass spectrometry imaging (MSI) has become a widespread analytical technique to perform
nonlabeled spatial molecular identification. The Achilles' heel of MSI is the annotation and …

Pharmaceutical analysis refers to an area of analytical chemistry that deals with active
compounds either by themselves (drug substance) or when formulated with excipients (drug …

Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution
of various molecules in biological samples, and it is widely used in pathology‐related …

The lens is an important determinant of overall vision quality whose refractive and
transparent properties change throughout life. Alterations to the refractive properties of the …

The small heat shock protein αA-crystallin is a molecular chaperone important for the optical
properties of the vertebrate eye lens. It forms heterogeneous oligomeric ensembles. We …

Ocular tissues possess a robust antioxidant defence system to minimize oxidative stress and
preserve tissue structure and function. Glutathione (GSH) is a powerful antioxidant and in …

Dysfunctional lens syndrome (DLS) is a term coined to describe the natural aging changes
in the crystalline lens. Different alterations in the refractive properties and transparency of …

Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can
provide valuable insights into the metabolome of complex biological systems such as organ …