N Takeda, K Maemura - Hypertension Research, 2016 - nature.com
The onset of cardiovascular diseases often shows time-of-day variation. Acute myocardial infarction or ventricular arrhythmia such as ventricular tachycardia occurs mainly in the early …
Time plays a crucial role in the regulation of physiological processes. Without a temporal control system, animals would be unprepared for cyclic environmental changes, negatively …
K Maemura, N Takeda, R Nagai - Journal of pharmacological sciences, 2007 - Elsevier
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the …
N Takeda, K Maemura - Cellular and molecular life sciences, 2015 - Springer
The time of onset of cardiovascular disorders such as myocardial infarctions or ventricular arrhythmias exhibits a circadian rhythm. Diurnal variations in autonomic nervous activity …
ME Young - Basic to Translational Science, 2023 - jacc.org
Virtually all aspects of physiology fluctuate with respect to the time of day. This is beautifully exemplified by cardiovascular physiology, for which blood pressure and electrophysiology …
N Takeda, K Maemura - Hypertension research, 2010 - nature.com
Cardiovascular functions, including blood pressure and vascular functions, show diurnal oscillation. Circadian variations have been clearly shown in the occurrence of …
B Tunçtan, Y Weigl, A Dotan, L Peleg… - Chronobiology …, 2002 - Taylor & Francis
Endogenous nitric oxide (NO) is an important mediator in the processes that control biological clocks and circadian rhythms. The present study was designed to elucidate if NO …
N Takeda, K Maemura - Advanced drug delivery reviews, 2010 - Elsevier
Cardiovascular functions such as heart rate and blood pressure show 24h variation. The incidence of cardiovascular diseases including acute myocardial infarction and arrhythmia …
K Witte, T Hasenberg, T Rueff… - Chronobiology …, 2001 - Taylor & Francis
TGR (mREN2) 27 (TGR) rats develop severe hypertension and an inverted circadian blood pressure profile with peak blood pressure in the daytime rest phase. The present study …