The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function

ME Young - American Journal of Physiology-Heart and …, 2006 - journals.physiology.org
It is becoming increasingly clear that the intrinsic properties of both the heart and
vasculature exhibit dramatic oscillations over the course of the day. Diurnal variations in the …

Circadian clock and the onset of cardiovascular events

N Takeda, K Maemura - Hypertension Research, 2016 - nature.com
The onset of cardiovascular diseases often shows time-of-day variation. Acute myocardial
infarction or ventricular arrhythmia such as ventricular tachycardia occurs mainly in the early …

Circadian de (regulation) in physiology: implications for disease and treatment

LVM de Assis, A Kramer - Genes & Development, 2024 - genesdev.cshlp.org
Time plays a crucial role in the regulation of physiological processes. Without a temporal
control system, animals would be unprepared for cyclic environmental changes, negatively …

Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases

K Maemura, N Takeda, R Nagai - Journal of pharmacological sciences, 2007 - Elsevier
The cardiovascular diseases are closely related to circadian rhythm, which is under the
control of the biological clock. Clock genes show circadian oscillation not only in the …

The role of clock genes and circadian rhythm in the development of cardiovascular diseases

N Takeda, K Maemura - Cellular and molecular life sciences, 2015 - Springer
The time of onset of cardiovascular disorders such as myocardial infarctions or ventricular
arrhythmias exhibits a circadian rhythm. Diurnal variations in autonomic nervous activity …

The cardiac circadian clock: implications for cardiovascular disease and its treatment

ME Young - Basic to Translational Science, 2023 - jacc.org
Virtually all aspects of physiology fluctuate with respect to the time of day. This is beautifully
exemplified by cardiovascular physiology, for which blood pressure and electrophysiology …

Circadian clock and vascular disease

N Takeda, K Maemura - Hypertension research, 2010 - nature.com
Cardiovascular functions, including blood pressure and vascular functions, show diurnal
oscillation. Circadian variations have been clearly shown in the occurrence of …

Circadian variation of nitric oxide synthase activity in mouse tissue

B Tunçtan, Y Weigl, A Dotan, L Peleg… - Chronobiology …, 2002 - Taylor & Francis
Endogenous nitric oxide (NO) is an important mediator in the processes that control
biological clocks and circadian rhythms. The present study was designed to elucidate if NO …

Cardiovascular disease, chronopharmacotherapy, and the molecular clock

N Takeda, K Maemura - Advanced drug delivery reviews, 2010 - Elsevier
Cardiovascular functions such as heart rate and blood pressure show 24h variation. The
incidence of cardiovascular diseases including acute myocardial infarction and arrhythmia …

Day-night variation in the in vitro contractility of aorta and mesenteric and renal arteries in transgenic hypertensive rats

K Witte, T Hasenberg, T Rueff… - Chronobiology …, 2001 - Taylor & Francis
TGR (mREN2) 27 (TGR) rats develop severe hypertension and an inverted circadian blood
pressure profile with peak blood pressure in the daytime rest phase. The present study …