Abstract Glycoside hydrolase family 18 (GH18) chitinases, which catalyze the
biodegradation of β-1, 4 glycosidic bond in amino polysaccharides via a substrate-assisted …

Sustainable agriculture requires insecticides that are selective between insects and
mammals and even between harmful and beneficial insects. Lepidoptera includes the …

In structure-based virtual screening (SBVS), a binding site on a protein structure is used to
search for ligands with favorable nonbonded interactions. Because it is computationally …

Camptothecin (CPT) is a prominent molecule in natural product research because of its
application prospects in medicine and agriculture. In this study, CPT and its derivatives were …

Chitinases belong to the evolutionarily conserved glycosyl hydrolase family 18 (GH18). They
catalyze degradation of chitin to N-acetylglucosamine by hydrolysis of the β-(1-4)-glycosidic …

Multitarget inhibitors of insect chitinolytic enzymes are promising sources of green
insecticides. Machine learning (ML) is an emerging virtual screening method that can …

Small-molecule inhibitors of insect chitinolytic enzymes are potential insecticides. However,
the reported inhibitors that target one enzyme usually exhibit unsatisfactory bioactivity. On …

Insect growth regulators (IGRs) are important insecticides that reduce the harm caused by
insects to crops by controlling pest population growth. Chitinases are closely associated with …

Asian corn borer (Ostrinia furnacalis) is one of the most destructive pests in agriculture.
Three chitinases Of ChtI, Of ChtII, and Of Chi-h are regarded as potential targets for …

Chitinase is one of the most important glycoside hydrolyases, widely existing in bacteria,
fungi, insects, and plants. It is involved in fungal cell wall remodeling and insect molting …