Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Recent progress in research on drug‐induced liver injury (DILI) has been determined by key
developments in two areas. First, new technologies allow the identification of genetic risk …

Introduction: Idiosyncratic drug induced liver injury (DILI) is rare, with an incidence of
approximately 19 per 100,000 treated individuals. Areas covered: An update on the …

Genetic polymorphisms of human arylamine N-acetyltransferase 2 (NAT2) are responsible
for interindividual variation in the acetylation of numerous drugs and in the transformation of …

Aim The aim of this study was to obtain pharmacogenetic data in a Vietnamese population
on genes coding for proteins involved in the elimination of drugs currently used for the …

Methods: NAT2 genotyping of 201 subjects was carried out by PCR-restriction fragment
length polymorphism (PCR-RFLP) analysis and DNA sequencing. Acetylation phenotypes …

Background Numerous studies have attempted to relate genetic polymorphisms within the N-
acetyltransferase 2 gene (NAT2) to interindividual differences in response to drugs or in …

The objectives of this study are to investigate allele frequencies of drug absorption,
distribution, metabolism and elimination (ADME)-related genes in the Thai population and to …

Arylamine N-acetyltransferases (NAT) are important enzymes involved in the metabolic
activation of aromatic and heterocyclic amines and inhibitors of NAT enzymes may be …

Polymorphisms of arylamine N-acetyltransferase 2 (NAT2) are reportedly associated with
the risk of drug toxicities and development of various diseases. The present study examined …