University of California, San Francisco stimulation. Through these diverse mechanisms,
adhesion, deadhesion, and ECM proteolysis are all brought San Francisco, California …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

Abstract Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt
signaling pathway, which promote the phosphorylation and degradation of β-catenin. While …

In the mammalian embryo, both sexes are initially morphologically indistinguishable:
specific hormones are required for sex-specific development. Müllerian inhibiting substance …

Background & Aims: In the intestine, the canonical Wnt signaling cascade plays a crucial
role in driving the proliferation of epithelial cells. Furthermore, aberrant activation of Wnt …

During kidney development and in response to inductive signals, the metanephric
mesenchyme aggregates, becomes polarized, and generates much of the epithelia of the …

Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles
for WNT proteins in this process. We show that expression of Wnts 10b and 10a is …

Development of the mammalian kidney is initiated by ingrowth of the ureteric bud into the
metanephric blastema. In response to signal (s) from the ureter, mesenchymal cells …

Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

Reciprocal cell-cell interactions between the ureteric epithelium and the metanephric
mesenchyme are needed to drive growth and differentiation of the embryonic kidney to …