Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Peripheral nerve injury is a complex condition with a variety of signs and symptoms such as
numbness, tingling, jabbing, throbbing, burning or sharp pain. Peripheral nerves are fragile …

Mesenchymal stem cells (MSCs) are promising tools for the treatment of diseases such as
infarcted myocardia and strokes because of their ability to promote endogenous …

Despite the ability of peripheral nerves to spontaneously regenerate after injury, recovery is
generally very poor. The neurotrophins have emerged as an important modulator of axon …

Peripheral axons of dorsal root ganglion (DRG) neurons, but not their central axons in the
dorsal columns, regenerate after injury. However, if the neurons are conditioned by a …

Peripheral nerves are easily damaged, resulting in loss of motor and sensory function.
Recovery of motor and sensory function after peripheral nerve injury is suboptimal, even …

Although neurons within the peripheral nervous system (PNS) have a remarkable ability to
repair themselves after injury, neurons within the central nervous system (CNS) do not …

Transcription factors are master regulators of various cellular processes under diverse
physiological and pathological conditions. Many transcription factors that are differentially …

Brain-derived neurotrophic factor (BDNF) is a key positive regulator of neural plasticity,
promoting, for example, the actions of stimulant drugs of abuse such as cocaine. We …

A major reason for the devastating and permanent disabilities after spinal cord and other
types of CNS injury is the failure of injured axons to regenerate and to re-build the functional …