With the arrival of atomic force microscopy (AFM) about thirty years ago, this new imaging
tool opened up a new area for the exploration of biological samples, ranging from the tissue …

The structural-functional hallmark of the liver sinusoidal endothelium is the presence of
fenestrae grouped in sieve plates. Fenestrae are open membrane bound pores supported …

Healthy liver sinusoidal endothelial cells (LSECs) maintain liver homeostasis, while LSEC
dysfunction was suggested to coincide with defenestration. Here, we have revisited the …

Here, we report an atomic force microscopy (AFM)-based imaging method for resolving the
fine nanostructures (eg, fenestrations) in the membranes of live primary murine liver …

Background Liver sinusoidal endothelial cells (LSECs) display unique fenestrated
morphology. Alterations in the size and number of fenestrae play a crucial role in the …

Liver sinusoidal endothelial cells (LSECs) occupy a strategic position in the liver, separating
blood in the sinusoid from the extracellular space of Disse and surrounding sheets of …

Fenestrae are open transmembrane pores that are a structural hallmark of healthy liver
sinusoidal endothelial cells (LSECs). Their key role is the transport of solutes and …

Super-resolution fluorescence microscopy, also known as nanoscopy, has provided us with
a glimpse of future impacts on cell biology. Far-field optical nanoscopy allows, for the first …

Liver sinusoidal endothelial cells present unique morphology characterized by the presence
of transmembrane pores called fenestrations. The size and number of fenestrations in live …

In this work, we presented a method of finding and characterising transmembrane porous
structures, called fenestrations, with the help of convolutional neural networks. Case studies …