In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

Malaria is a vector‐borne infectious disease caused by unicellular parasites of the genus
Plasmodium. These obligate intracellular parasites have the unique capacity to infect and …

Malaria remains the most prevalent vector-borne infectious disease and has the highest
rates of fatality. Current antimalarial drug strategies cure malaria or prevent infections but …

The quest for an efficacious malaria vaccine has been ongoing for nearly a century with
limited success. Malaria remains one of the most significant infectious diseases affecting …

The concept of a malaria vaccine has sparked great interest for decades; however, the
challenge is proving to be a difficult one. Immune dysregulation by Plasmodium and the …

Several species of Plasmodium cause a broad spectrum of human disease that range from
nausea and fever to severe anemia, cerebral malaria, and multiorgan failure. In malaria …

The Plasmodium parasite, the causative agent of malaria, is an excellent model for
immunomic-based approaches to vaccine development. The Plasmodium parasite has a …

Tissue-resident memory CD8+ T (Trm) cells in the liver are critical for long-term protection
against pre-erythrocytic Plasmodium infection. Such protection can usually be induced with …

Immunization with irradiated sporozoites is currently the most effective vaccination strategy
against liver stages of malaria parasites, yet the mechanisms underpinning the success of …

CD8+ T cells mediate immunity against Plasmodium liver stages. However, the paucity of
parasite-specific epitopes of CD8+ T cells has limited our current understanding of the …