A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both
aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in …

Immunotherapies have revolutionized the treatment of certain cancers, but challenges
remain in overcoming immunotherapy resistance. Research shows that metabolic …

Although immune-based therapies have revolutionized the management of cancer, novel
approaches are urgently needed to improve their outcome. We investigated the role of …

Esophageal cancer (EC), including esophageal squamous cell carcinoma (ESCC) and
esophageal adenocarcinoma (EAC), ranks as the eighth most common malignancy …

Figure 1. Glucocorticoid-producing enzyme expression in tumors.(A) Relative Hsd11b1,
Cyp11b1, and Cyp11b2 expression (corrected for Gapdh) in tumor cells was determined by …

Melanoma, originating through malignant transformation of melanin-producing melanocytes,
is a formidable malignancy, characterized by local invasiveness, recurrence, early …

As single‐cell RNA sequencing enables the detailed clustering of T‐cell subpopulations and
facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained …

Background Although the use of anti-PD-1 antibodies has fundamentally changed traditional
cancer treatment, most patients are resistant to anti-PD-1 treatment. Glucocorticoids (GCs) …

Cellular differentiation allows cells to transition between different functional states and adapt
to various environmental cues. The diversity and plasticity of this process is beautifully …

This study aimed to investigate the diagnostic value of miR-451a, miR-5571-3p, CLN6,
HSD11B1, and PDE4 as potential biomarkers for distinguishing patients with …